Graphics Card and Hardware Requirementīoth Fallout 4 and Windows 10 has many variables which can result in game crashes on your computer. Switch to Borderless Windowed Mode in Fallout 4 Video Settings
Run Fallout 4 in Compatibility Mode in Windows 10 Update Graphics Card Driver via Device Manager in Windows 10 Verify Local Game Files Integrity via Steam How to Fix Fallout 4 Crash on Startup on Windows 10.